Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.

  title={Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.},
  author={Gunter Schumann and Lachlan J Coin and Anbarasu Lourdusamy and Pimphen Charoen and Karen H. Berger and David Stacey and Sylvane Desrivi{\`e}res and Fazil A. Aliev and Anokhi Ali Khan and Najaf Amin and Yurii S. Aulchenko and Georgy Bakalkin and Stephan J Bakker and Beverley Balkau and Joline W Beulens and Ainhoa Bilbao and Rudolf A de Boer and Delphine Beury and Michiel L. Bots and Elemi J Breetvelt and St{\'e}phane Cauchi and Christine Cavalcanti-Proença and John C Chambers and Toni-Kim Clarke and Norbert Dahmen and Eco J de Geus and Danielle M Dick and Francesca Ducci and Alanna C. Easton and Howard J. Edenberg and T{\"o}nu Esko and Alberto Fern{\'a}ndez-Medarde and Tatiana Foroud and Nelson B. Freimer and Jean-Antoine Girault and Diederick E Grobbee and Simonetta Guarrera and Daniel Fannar Gudbjartsson and Anna-Liisa Hartikainen and Andrew C Heath and Victor M. Hesselbrock and Albert Hofman and Jouke-Jan Hottenga and Matti Isohanni and Jaakko Kaprio and Kay-Tee Khaw and Brigitte Kuehnel and Jaana H. Laitinen and St{\'e}phane Lobbens and Jian'an Luan and Massimo Mangino and Matthieu J Maroteaux and Giuseppe Matullo and Mark I. McCarthy and Christian Mueller and Gerjan Navis and Mattijs E. Numans and Alejandro N{\'u}{\~n}ez and Dale R. Nyholt and Charlotte N Onland-Moret and Ben A. Oostra and Paul F. O'Reilly and Mikl{\'o}s Palkovits and Brenda W Penninx and Silvia Polidoro and Anneli Pouta and Inga Prokopenko and Fulvio Ricceri and Eugenio Santos and Johannes H Smit and Nicole Soranzo and Kijoung Song and Ulla Sovio and Michael Stumvoll and Ida Surakk and Thorgeir E. Thorgeirsson and Unnur Thorsteinsdottir and Claire Troakes and Thorarinn Tyrfingsson and Anke Toenjes and Cuno S Uiterwaal and Andr{\'e} G. Uitterlinden and Pim van der Harst and Yvonne T van der Schouw and Oliver Staehlin and Nicole Vogelzangs and Peter Vollenweider and Gerard Waeber and Nicholas J Wareham and Dawn Waterworth and John B. Whitfield and Erich H. Wichmann and Gonneke A H M Willemsen and Jacqueline C Witteman and Xin Yuan and Guangju Zhai and Jing Hua Zhao and Weihua Zhang and Nicholas G. Martin and Andres Metspalu and Angela Doering and James Scott and Tim D. Spector and Ruth J Loos and Dorret I. Boomsma and Vincent Mooser and Leena Peltonen and Kari Stefansson and Cornelia M van Duijn and Paolo Vineis and Wolfgang H Sommer and Jaspal Singh Kooner and Rainer Spanagel and Ulrike A Heberlein and Marjo-Riitta Jarvelin and Paul Elliott},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 17},
Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption (gram per day per kilogram body weight) among 12 population-based samples of European ancestry, comprising 26,316 individuals, with replication genotyping in an additional 21,185 individuals. SNP rs6943555 in autism… CONTINUE READING
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