Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand

@article{denHollander2017GenomewideAA,
  title={Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand},
  author={Wouter J den Hollander and Cindy Germaine Boer and Deborah Hart and Michelle S Yau and Yolande F. M. Ramos and Sarah Metrustry and Linda Broer and Joris Deelen and L. Adrienne Cupples and Fernando Rivadeneira and Margreet Kloppenburg and Marjolein J. Peters and Tim D. Spector and Albert Hofman and Pieternella E Slagboom and Rob G. H. H. Nelissen and Andr{\'e} G. Uitterlinden and David T. Felson and Ana M. Valdes and Ingrid Meulenbelt and Joyce B.J. van Meurs},
  journal={Annals of the Rheumatic Diseases},
  year={2017},
  volume={76},
  pages={2046 - 2053}
}
Objective Osteoarthritis (OA) is the most common form of arthritis and the leading cause of disability in the elderly. Of all the joints, genetic predisposition is strongest for OA of the hand; however, only few genetic risk loci for hand OA have been identified. Our aim was to identify novel genes associated with hand OA and examine the underlying mechanism. Methods We performed a genome-wide association study of a quantitative measure of hand OA in 12 784 individuals (discovery: 8743… Expand
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