Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

  title={Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer},
  author={Kyriaki Michailidou and Jonathan Beesley and Sara Lindstrom and Sander Canisius and Joe G Dennis and Michael Lush and Mel J. Maranian and Manjeet K. Bolla and Qin Wang and Mitul H. Shah and Barbara J. Perkins and Kamila Czene and Mikael Eriksson and Hatef Darabi and Judith S Brand and Stig Egil Bojesen and B{\o}rge G. Nordestgaard and Henrik Flyger and Sune Fallgaard Nielsen and Nazneen Rahman and Clare Turnbull and Olivia Fletcher and Julian Peto and Lorna J. Gibson and Isabel Dos-Santos-Silva and Jenny Chang-Claude and Dieter Flesch-Janys and Anja Rudolph and Ursula Eilber and Sabine Behrens and Heli Nevanlinna and Taru A Muranen and Kristiina Aittom{\"a}ki and Carl Blomqvist and Sofia Khan and Kirsimari Aaltonen and Habibul Ahsan and Muhammad G Kibriya and Alice S. Whittemore and Esther M John and Kathleen E. Malone and Marilie Denise Gammon and Regina M. Santella and Giske Ursin and Enes Makalic and Daniel F. Schmidt and Graham R. Casey and David J. Hunter and Susan M Gapstur and Mia M Gaudet and W Ryan Diver and Christopher A. Haiman and Fredrick R Schumacher and Brian E. Henderson and Lo{\"i}c Le Marchand and Cornelis van den Berg and Stephen J. Chanock and Jonine D Figueroa and Robert Nathaniel Hoover and Diether Lambrechts and Patrick Neven and Hans Wildiers and Erik van Limbergen and Marjanka K Schmidt and Annegien Broeks and S. Cornelis Verhoef and Sten Cornelissen and Fergus J. Couch and Janet E. Olson and Emily J Hallberg and Celine M. Vachon and Quinten Waisfisz and Hanne Meijers-Heijboer and Muriel A. Adank and Rob B van der Luijt and Jingmei Li and Jianping Liu and Keith N Humphreys and Daehee Kang and Ji-Yeob Choi and Sue Kyung Park and Keun-young Yoo and Keitaro Matsuo and Hidemi Ito and Hiroji Iwata and Kazuo Tajima and Pascal Gu{\'e}nel and Th{\'e}r{\`e}se Truong and Claire Mulot and M. C. Pe{\~n}as Sanchez and Barbara Burwinkel and Frederik Marm{\'e} and Harald M. Surowy and Christof Sohn and Anna H Wu and Chiu-chen Tseng and David van den Berg and Daniel O. Stram and Anna Gonz{\'a}lez-Neira and Javier Ben{\'i}tez and Mar{\'i}a Pilar Mart{\'i}n Zamora and Jos{\'e} Ignacio Arias P{\'e}rez and Xiao-Ou Shu and Wei Lu and Yu-tang Gao and Hui Cai and Angela Cox and Simon S. Cross and Malcolm W. R. Reed and Irene L Andrulis and J. A. G. Knight and Gordon Glendon and Anna Marie Mulligan and Elinor J. Sawyer and Ian P. M. Tomlinson and Michael John Kerin and Nicola M Miller and A. Arto Lindblom and Sara Margolin and Soo Hwang Teo and Cheng-Har Yip and Nur Aishah Mohd Taib and Gie-Hooi Tan and Maartje J. Hooning and Antoinette Hollestelle and John W. M. Martens and J Margriet Coll{\'e}e and William J. Blot and Lisa B. Signorello and Qiuyin Cai and John L. Hopper and Melissa C. Southey and Helen Tsimiklis and Carmel Apicella and Chen-yang Shen and Cheng Sheng Hsiung and Pingfan Peter Wu and Ming-Feng Hou and Vessela N. Kristensen and Silje H Nord and Grethe I Grenaker Alnaes and Graham G. Giles and Roger L Milne and Catriona A. McLean and Frederico Canzian and Dimitrios Trichopoulos and P. H. Peeters and Eiliv Lund and Malin Sund and Kay-Tee Khaw and Marc James Gunter and Domenico Palli and Lotte Maxild Mortensen and Laure Dossus and Jos{\'e}-Mar{\'i}a Huerta and Alfons Meindl and Rita Katharina Schmutzler and Christian Sutter and Rongxi Yang and Kenneth Ross Muir and Artitaya Lophatananon and Sarah Lynette Stewart-Brown and Pornthep Siriwanarangsan and M. Hartman and Hui Miao and Kee Seng Chia and Ching Chan and Peter A. Fasching and Alexander Hein and Matthias W. Beckmann and Lothar Haeberle and Hermann Brenner and Aida Karina Dieffenbach and Volker Arndt and Christa Stegmaier and Alan A. Ashworth and Nick Orr and Minouk J Schoemaker and Anthony J Swerdlow and Louise A Brinton and Montserrat Garc{\'i}a-Closas and Wei Zheng and Sandra L. Halverson and Martha J. Shrubsole and Jirong Long and Mark S. Goldberg and France Labr{\`e}che and Martine Dumont and Robert Winqvist and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Mervi Grip and Hiltrud Brauch and Ute Hamann and Thomas Br{\"u}ning and Paolo Radice and Paolo Peterlongo and Siranoush Manoukian and Loris Bernard and Natalia Valerijevna Bogdanova and Thilo D{\"o}rk and Arto J Mannermaa and Vesa V. Kataja and V. M. Kosma and Jaana M. Hartikainen and Peter Devilee and Robert Aem Tollenaar and Caroline M. Seynaeve and Christi J. van Asperen and Anna Jakubowska and Jan Lubiński and Katarzyna Jaworska and Tomasz Huzarski and Suleeporn Sangrajrang and Val{\'e}rie Gaborieau and Paul J Brennan and James McKay and Susan L. Slager and Amanda Ewart Toland and Christine B. Ambrosone and Drakoulis Yannoukakos and Maria Kabisch and Diana Ramos Torres and Susan L. Neuhausen and Hoda Anton-Culver and Craig Luccarini and Caroline Baynes and Shahana Ahmed and Catherine S. Healey and Daniel C. Tessier and Daniel D Vincent and François Bacot and Guillermo Pita and Mar{\'i}a Rosario Alonso and N{\'u}ria P{\'e}rez Alvarez and Daniel Pascual Herrero and Jacques Simard and Paul D. P. Pharoah and Peter Kraft and Alison M. Dunning and Georgia Chenevix-Trench and Philip F. Hall and Douglas F. Easton},
  booktitle={Nature Genetics},
Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European… CONTINUE READING

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