Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia

@article{Lan2012GenomewideAA,
  title={Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia},
  author={Q. Lan and C. Hsiung and K. Matsuo and Yun-Chul Hong and A. Seow and Z. Wang and H. Hosgood and K. Chen and Jiu-cun Wang and N. Chatterjee and Wei Hu and M. Wong and W. Zheng and N. Caporaso and J. Y. Park and Chien-Jen Chen and Yeul-Hong Kim and Y. Kim and M. Landi and Hongbing Shen and Charles Lawrence and L. Burdett and M. Yeager and J. Yuenger and K. Jacobs and I. Chang and T. Mitsudomi and H. N. Kim and G. Chang and B. Bassig and M. Tucker and F. Wei and Zhihua Yin and Chen Wu and S. An and B. Qian and V. Lee and D. Lu and Jianjun Liu and H. Jeon and C. Hsiao and J. Sung and J. Kim and Yu-tang Gao and Y. Tsai and Y. Jung and Huan Guo and Zhibin Hu and A. Hutchinson and Wen-Chang Wang and R. Klein and Charles C. Chung and I. Oh and Kuan-Yu Chen and S. Berndt and X. He and Wei Wu and J. Chang and Xuchao Zhang and Ming-Shyan Huang and Hong Zheng and Junwen Wang and Xueying Zhao and Yuqing Li and J. Choi and W. Su and K. Park and S. Sung and X. Shu and Yuh-Min Chen and L. Liu and C. Kang and Lingmin Hu and Chung-Hsing Chen and W. Pao and Young-Chul Kim and Tsung-Ying Yang and Jun Xu and P. Guan and W. Tan and J. Su and Chih-Liang Wang and Hai-xin Li and A. Sihoe and Zhenhong Zhao and Ying Chen and Y. Choi and J. Hung and Jun Suk Kim and H. Yoon and Q. Cai and Chien-Chung Lin and I. Park and P. Xu and Jingyan Dong and Christopher Kim and Qincheng He and R. Perng and T. Kohno and S. Kweon and Chih-Yi Chen and R. Vermeulen and J. Wu and W. Lim and Kun-Chieh Chen and W. Chow and B. Ji and J. Chan and M. Chu and Yao-Jen Li and J. Yokota and Jihua Li and Hongyan Chen and Y. Xiang and Chong-Jen Yu and H. Kunitoh and Guoping Wu and L. Jin and Y. Lo and K. Shiraishi and Ying-Hsiang Chen and Hsien-Chih Lin and Tangchun Wu and Yi-Long Wu and Pan-Chyr Yang and Baosen Zhou and M. Shin and J. Fraumeni and D. Lin and S. Chanock and N. Rothman},
  journal={Nature Genetics},
  year={2012},
  volume={44},
  pages={1330-1335}
}
To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hong Kong. We genotyped the most promising variants (associated at P < 5 × 10−6) in an additional 1,099 cases and 2,913 controls. We identified three… Expand
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References

SHOWING 1-10 OF 56 REFERENCES
Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population
TLDR
The results advance the understanding of lung cancer susceptibility and highlight potential pathways that integrate genetic variants and smoking in the development of lungcancer. Expand
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese
TLDR
Results suggest that genetic variants in 3q28, 5p15.33, 13q 12.12 and 22q12.2 may contribute to the susceptibility of lung cancer in Han Chinese. Expand
A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population
TLDR
A genome-wide association study and two validation studies in the Japanese population provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma. Expand
Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia
TLDR
There is strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking. Expand
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
TLDR
Two SNPs, rs1051730 and rs8034191, mapping to a region of strong linkage disequilibrium within 15q25.1 containing PSMA4 and the nicotinic acetylcholine receptor subunit genes CHRNA3 and CHRNA5, were significantly associated with risk in both replication sets. Expand
The 5p15.33 Locus Is Associated with Risk of Lung Adenocarcinoma in Never-Smoking Females in Asia
TLDR
Results show that genetic variation in the CLPTM1L-TERT locus of chromosome 5p15.33 is directly associated with the risk of lung cancer, most notably adenocarcinoma. Expand
Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations
TLDR
The results suggest that genetic variation in TP63 may influence susceptibility to lung adenocarcinoma in East Asian populations, and a SNP in intron 1 of TP63 showed the most significant association. Expand
Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium.
TLDR
Previous associations found in white populations were replicated and new associations were identified in Asian populations, and the associations between the 5p15 variants and lung cancer differed by histology; odds ratios for rs2736100 were highest in adenocarcinoma and for rs402710 were highest for squamous cell carcinomas. Expand
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.
TLDR
A lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma, and previously reported association signals on 15q25 and 6p21 were refined, but no additional loci reached genome-wide significance. Expand
Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations.
TLDR
15q25 is supported as a susceptibility region for lung cancer in Chinese but the difference in genetic markers among different ethnic populations is underscored. Expand
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