Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open angle glaucoma

  title={Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open angle glaucoma},
  author={Jessica N Cooke Bailey and Stephanie J. Loomis and Jae H Kang and Robert Rand Allingham and Puya Gharahkhani and Chiea Chuen Khor and Kathryn P Burdon and Hugues Aschard and Daniel Chasman and Robert P. Igo and Pirro G Hysi and Craig A. Glastonbury and Allison E. Ashley-Koch and Murray H. Brilliant and Andrew Anand Brown and Donald L Budenz and Alfonso Buil and Ching-Yu Cheng and Hyon K. Choi and William G. Christen and Gary C. Curhan and Immaculata de Vivo and John H. Fingert and Paul J Foster and Charles Fuchs and Douglas A Gaasterland and Terry Gaasterland and Alex W. Hewitt and Frank B Hu and David J. Hunter and Anthony P Khawaja and Richard Lee and Zheng Li and Paul R. Lichter and David A Mackey and Peter McGuffin and Paul Mitchell and Sayoko E. Moroi and Shamira A. Perera and Keating W. Pepper and Qibin Qi and Tony D Realini and Julia E. Richards and Paul M. Ridker and Eric B. Rimm and Robert Ritch and Marylyn DeRiggi Ritchie and Joel S Schuman and William K. Scott and Kuldev Singh and Arthur J. Sit and Yeunjoo E. Song and Rulla M. Tamimi and Fotis Topouzis and Ananth C. Viswanathan and Shefali S. Verma and Douglas Vollrath and Jie Jin Wang and Nicole Weisschuh and Bernd Wissinger and Gadi Wollstein and Tien Yin Wong and Brian L. Yaspan and Donald J. Zack and Kang Zhang and Epic-Norfolk Eye Study and Robert N. Weinreb and Margaret A. Pericak-Vance and Kerrin S. Small and Christopher J Hammond and Tin Aung and Yutao Liu and Eranga Vithana and Stuart Macgregor and Jamie Evan Craig and Peter Kraft and Gareth R. Howell and Michael A. Hauser and Louis R. Pasquale and Jonathan L. Haines and Janey L. Wiggs},
  booktitle={Nature Genetics},
Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. To identify new susceptibility loci, we performed meta-analysis on genome-wide association study (GWAS) results from eight independent studies from the United States (3,853 cases and 33,480 controls) and investigated the most significantly associated SNPs in two Australian studies (1,252 cases and 2,592 controls), three European studies (875 cases and 4,107 controls) and a Singaporean Chinese study (1,037 cases and 2… CONTINUE READING
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