Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

  title={Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression},
  author={Naomi R. Wray and Stephan Ripke and Manuel Mattheisen and Maciej Trzaskowski and Enda M. Byrne and Abdel Abdellaoui and Mark James Adams and Esben Agerbo and Tracy M. Air and Till F. M. Andlauer and Silviu-Alin Bacanu and Marie B{\ae}kvad-Hansen and Aartjan T. F. Beekman and T. Bernard Bigdeli and Elisabeth B. Binder and Douglas H.R. Blackwood and Julien Bryois and Henriette N{\o}rm{\o}lle Buttensch{\o}n and Jonas Bybjerg-Grauholm and Na Cai and Enrique Castelao and Jane Hvarregaard Christensen and Toni‐Kim Clarke and Jonathan R. I. Coleman and Luc{\'i}a Colodro-Conde and Baptiste Couvy-Duchesne and Nick Craddock and Gregory E. Crawford and Cheynna A. Crowley and Hassan S. Dashti and Gail Davies and Ian J. Deary and Franziska Degenhardt and Eske M. Derks and Nese Direk and Conor V. Dolan and Erin C. Dunn and Thalia C. Eley and Nicholas Eriksson and Valentina Escott-Price and Farnush Farhadi Hassan Kiadeh and Hilary K. Finucane and Andreas J. Forstner and Josef Frank and Héléna A. Gaspar and Michael Gill and Paola Giusti-Rodr{\'i}guez and Fernando S. Goes and Scott D. Gordon and Jakob Grove and Lynsey S. Hall and Eilis J. Hannon and Christine S{\o}holm Hansen and Thomas Folkmann Hansen and Stefan Herms and Ian B. Hickie and Per Hoffmann and Georg Homuth and Carsten Horn and Jouke- Jan Hottenga and David Michael Hougaard and Ming Hu and Craig L. Hyde and Marcus Ising and Rick Jansen and Fulai Jin and Eric Jorgenson and James A. Knowles and Isaac S. Kohane and Julia Kraft and Warren W. Kretzschmar and Jesper Krogh and Zolt{\'a}n Kutalik and Jacqueline M. Lane and Yihan Li and Yun Li and Penelope A. Lind and Xiaoxiao Liu and Leina Lu and Donald J. Macintyre and Dean F. MacKinnon and Robert M Maier and Wolfgang Maier and Jonathan Marchini and Hamdi Mbarek and Patrick J. McGrath and Peter McGuffin and Sarah E. Medland and Divya Mehta and Christel M. Middeldorp and Evelin Mihailov and Yuri Milaneschi and Lili Milani and Jonathan Mill and Francis M. Mondimore and Grant W. Montgomery and Sara Mostafavi and Niamh Mullins and Matthias Nauck and Bernard Ng and Michel G. Nivard and Dale R. Nyholt and Paul F. O’Reilly and Hogni Oskarsson and Michael J. Owen and Jodie N. Painter and Carsten B{\o}cker Pedersen and Marianne Gi{\o}rtz Pedersen and Roseann E. Peterson and Erik Pettersson and Wouter J. Peyrot and Giorgio Pistis and Danielle Posthuma and Shaun M Purcell and Jorge A. Quiroz and Per Qvist and John P. Rice and Brien P. Riley and Margarita Rivera and Saira Saeed Mirza and Richa Saxena and Robert A. Schoevers and Eva C. Schulte and Ling Shen and Jianxin Shi and Stanley I. Shyn and Engilbert Sigurdsson and Grant C.B. Sinnamon and Johannes H. Smit and Danny J. Smith and Hreinn Stef{\'a}nsson and Stacy Steinberg and Craig A. Stockmeier and Fabian Streit and Jana Strohmaier and Katherine E. Tansey and Henning Teismann and Alexander Teumer and Wesley Kurt Thompson and Pippa A. Thomson and Thorgeir E. Thorgeirsson and Chao Tian and Matthew Traylor and Jens Treutlein and Vassily Trubetskoy and Andr{\'e} G. Uitterlinden and Daniel S Umbricht and Sandra Van der Auwera and Albert M. van Hemert and Alexander Viktorin and Peter M. Visscher and Yunpeng Wang and Bradley Todd Webb and Shantel Weinsheimer and J{\"u}rgen Wellmann and Gonneke Willemsen and Stephanie H. Witt and Yang Wu and Hualin S. Xi and Jian Yang and Futao Zhang and Volker Arolt and Bernhard T. Baune and Klaus Berger and Dorret I. Boomsma and Sven Cichon and Udo Dannlowski and Eco J. C. de Geus and J. Raymond DePaulo and Enrico Domenici and Katharina Domschke and T{\~o}nu Esko and Hans J{\"o}rgen Grabe and Steven P. Hamilton and Caroline Hayward and Andrew C. Heath and David A. Hinds and Kenneth S. Kendler and Stefan Kloiber and Glyn Lewis and Qingqin S. Li and Susanne Lucae and Pamela A. F. Madden and Patrik K. E. Magnusson and Nicholas G. Martin and Andrew M. McIntosh and Andres Metspalu and Ole Mors and Preben Bo Mortensen and Bertram M{\"u}ller-Myhsok and Merete Nordentoft and Markus M. N{\"o}then and Michael C. O’Donovan and S A Paciga and Nancy L. Pedersen and Brenda W.J.H. Penninx and Roy H. Perlis and David J. Porteous and James B. Potash and Martin Preisig and Marcella Rietschel and Catherine Schaefer and Thomas G. Schulze and Jordan W. Smoller and K{\'a}ri Stef{\'a}nsson and Henning Tiemeier and Rudolf Uher and Henry V{\"o}lzke and Myrna M. Weissman and Thomas M. Werge and Ashley R Winslow and Cathryn M. Lewis and Douglas F. Levinson and Gerome D. Breen and Anders Dupont B{\o}rglum and Patrick F. Sullivan},
  journal={Nature genetics},
  pages={668 - 681}
Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved… 

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