Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2

@article{Thye2010GenomewideAA,
  title={Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2},
  author={T. Thye and F. Vannberg and S. Wong and E. Owusu-Dabo and I. Osei and J. Gyapong and G. Sirugo and F. Sisay-Joof and A. Enimil and M. A. Chinbuah and S. Floyd and D. Warndorff and L. Sichali and S. Malema and A. Crampin and B. Ngwira and Y. Teo and K. Small and K. Rockett and D. Kwiatkowski and P. Fine and P. Hill and M. Newport and C. Lienhardt and R. Adegbola and T. Corrah and A. Ziegler and A. Morris and C. Meyer and R. Horstmann and A. Hill},
  journal={Nature genetics},
  year={2010},
  volume={42},
  pages={739 - 741}
}
We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 × 10−9, odds ratio = 1.19, 95% CI = 1.13–1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium… Expand
Common variants at 11p13 are associated with susceptibility to tuberculosis
After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13Expand
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Fine mapping of genetic polymorphisms of pulmonary tuberculosis within chromosome 18q11.2 in the Chinese population: a case-control study
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Association of polymorphisms in the Chr18q11.2 locus with tuberculosis in Chinese population
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The results provided an independent support for a role in susceptibility to TB for SNP rs4331426 and indicated that direct predisposition element to TB and the association effects may vary across ethnic groups. Expand
An HLA class II locus, previously identified by a genome-wide association study, is also associated with susceptibility to pulmonary tuberculosis in a Chinese population.
  • R. Miao, Shuran Huang, +6 authors Haibo Ge
  • Biology, Medicine
  • Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • 2018
TLDR
It is found that the HLA class II locus also affects the susceptibility to PTB in Chinese population, and the association results were similar between the microbiologically negative and positive cases. Expand
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