Genome-wide assessment of recurrent genomic imbalances in canine leukemia identifies evolutionarily conserved regions for subtype differentiation

@article{Roode2015GenomewideAO,
  title={Genome-wide assessment of recurrent genomic imbalances in canine leukemia identifies evolutionarily conserved regions for subtype differentiation},
  author={Sarah C. Roode and Daniel Rotroff and Anne C. Avery and Steven E. Suter and Dorothee Bienzle and Joshua D Schiffman and Alison A. Motsinger-Reif and Matthew Breen},
  journal={Chromosome Research},
  year={2015},
  volume={23},
  pages={681-708}
}
Leukemia in dogs is a heterogeneous disease with survival ranging from days to years, depending on the subtype. Strides have been made in both human and canine leukemia to improve classification and understanding of pathogenesis through immunophenotyping, yet classification and choosing appropriate therapy remains challenging. In this study, we assessed 123 cases of canine leukemia (28 ALLs, 24 AMLs, 25 B-CLLs, and 46 T-CLLs) using high-resolution oligonucleotide array comparative genomic… CONTINUE READING
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