Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors.

  title={Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors.},
  author={Christopher Hackett and John Graeme Hodgson and Mark E Law and Jane Fridlyand and Kazutoyo Osoegawa and Pieter J de Jong and Norma J. Nowak and Daniel Pinkel and Donna Albertson and Ajay Jain and R. H. Jenkins and Joe W. Gray and William S. Weiss},
  journal={Cancer research},
  volume={63 17},
Neuroblastoma, the third most common tumor of childhood, is a complex disease in which few genetic mutations have been identified.Mice expressing a human MYCN oncogene driven by the rat tyrosine hydroxylase promoter (TH-MYCN) represent an animal model for this disorder. We performed microarray-based comparative genomic hybridization analysis on murine tumors, identifying gains on chromosomes 1, 3, 11, 14, 17, and 18 and losses on chromosomes 5, 9, and 16. Fluorescence in situ hybridization… CONTINUE READING
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