Genome-wide application of RNAi to the discovery of potential drug targets.

  title={Genome-wide application of RNAi to the discovery of potential drug targets.},
  author={Masanori Ito and Kenji Kawano and Makoto Miyagishi and Kazunari Taira},
  journal={FEBS letters},
  volume={579 26},
Progress is being made in the development of RNA interference-based (RNAi-based) strategies for the control of gene expression. It has been demonstrated that small interfering RNAs (siRNAs) can silence the expression of target genes in a sequence-specific manner in mammalian cells. Various groups, including our own, have developed systems for vector-mediated specific RNAi. Vector-based siRNA- (or shRNA) expression libraries directed against the entire human genome and siRNA libraries based on… CONTINUE READING

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