Genome-wide and expression-profiling analyses suggest the main cytochrome P450 genes related to pyrethroid resistance in the malaria vector, Anopheles sinensis (Diptera Culicidae).

@article{Yan2018GenomewideAE,
  title={Genome-wide and expression-profiling analyses suggest the main cytochrome P450 genes related to pyrethroid resistance in the malaria vector, Anopheles sinensis (Diptera Culicidae).},
  author={Zheng-Wen Yan and Z He and Zhen-Tian Yan and Feng-Ling Si and Yong Zhou and Baiyu Chen},
  journal={Pest management science},
  year={2018},
  volume={74 8},
  pages={
          1810-1820
        }
}
BACKGROUND Anopheles sinensis is one of the major malaria vectors. However, pyrethroid resistance in An. sinensis is threatening malaria control. Cytochrome P450-mediated detoxification is an important pyrethroid resistance mechanism that has been unexplored in An. sinensis. In this study, we performed a comprehensive analysis of the An. sinensis P450 gene superfamily with special attention to their role in pyrethroid resistance using bioinformatics and molecular approaches. RESULTS Our data… CONTINUE READING
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