Genome-wide analysis yields new loci associating with aortic valve stenosis

  title={Genome-wide analysis yields new loci associating with aortic valve stenosis},
  author={Anna Helgadottir and Gudmar Thorleifsson and Solveig Gretarsdottir and Olafur Stefansson and Vinicius Tragante and Rosa B. Thorolfsdottir and Ingileif J{\'o}nsd{\'o}ttir and Thorsteinn Bjornsson and Valgerdur Steinthorsdottir and Niek Verweij and Jonas Bille Nielsen and Wei Zhou and Lasse Folkersen and Andreas Martinsson and Mahyar Heydarpour and Siddharth K Prakash and Gylfi Oskarsson and Tomas Gudbjartsson and Arnar Geirsson and Isleifur Olafsson and Emil L. Sigurdsson and Peter Almgren and Olle Melander and Anders Franco-Cereceda and Anders Hamsten and Lars G Fritsche and Maoxuan Lin and Bo Yang and Whitney E. Hornsby and Dongchuan Guo and Chad M. Brummett and Gonçalo R. Abecasis and Michael R. Mathis and Dianna Milewicz and Simon C Body and Per Eriksson and Cristen J. Willer and Kristian Hveem and Christopher H. Newton-Cheh and Jan Gustav Smith and Ragnar Dan{\'i}elsen and Gudmundur Thorgeirsson and Unnur Thorsteinsdottir and Daniel Fannar Gudbjartsson and Hilma H{\'o}lm and K{\'a}ri Stef{\'a}nsson},
Aortic valve stenosis (AS) is the most common valvular heart disease, characterized by a thickened and calcified valve causing left ventricular outflow obstruction. Severe AS is a significant cause of morbidity and mortality, affecting approximately 5% of those over 70 years of age. Little is known about the genetics of AS, although recently a variant at the LPA locus and a rare MYH6 missense variant were found to associate with AS. We report a large genome-wide association study (GWAS) with a… CONTINUE READING