Genome-wide analysis shows increased frequency of copy number variation deletions in Dutch schizophrenia patients.

@article{BuizerVoskamp2011GenomewideAS,
  title={Genome-wide analysis shows increased frequency of copy number variation deletions in Dutch schizophrenia patients.},
  author={Jacobine E. Buizer-Voskamp and J W Muntjewerff and Eric Strengman and Chiara Sabatti and Hreinn Stefansson and Jacob A. S. Vorstman and Roel A. Ophoff},
  journal={Biological psychiatry},
  year={2011},
  volume={70 7},
  pages={655-62}
}
BACKGROUND Since 2008, multiple studies have reported on copy number variations (CNVs) in schizophrenia. However, many regions are unique events with minimal overlap between studies. This makes it difficult to gain a comprehensive overview of all CNVs involved in the etiology of schizophrenia. We performed a systematic CNV study on the basis of a homogeneous genome-wide dataset aiming at all CNVs ≥ 50 kilobase pair. We complemented this analysis with a review of cytogenetic and chromosomal… CONTINUE READING

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