Genome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone

@article{Meyer2010GenomewideAO,
  title={Genome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone},
  author={Mark B. Meyer and Paul D Goetsch and John Wesley Pike},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2010},
  volume={121},
  pages={136-141}
}
The vitamin D receptor (VDR) mediates the actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in target cells and tissues by orchestrating the expression of gene networks responsible for vitamin D-induced phenotypes. The molecular mechanisms of these regulatory systems have been studied for decades under the principle that transcriptional regulation occurs near the transcriptional start site of the gene. However, this now appears to be an outdated view of transcriptional control. In this study… CONTINUE READING
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