Genome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone

@article{Meyer2010GenomewideAO,
  title={Genome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone},
  author={Mark B Meyer and Paul D Goetsch and J. Pike},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2010},
  volume={121},
  pages={136-141}
}
  • Mark B Meyer, Paul D Goetsch, J. Pike
  • Published 2010
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
  • The vitamin D receptor (VDR) mediates the actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in target cells and tissues by orchestrating the expression of gene networks responsible for vitamin D-induced phenotypes. The molecular mechanisms of these regulatory systems have been studied for decades under the principle that transcriptional regulation occurs near the transcriptional start site of the gene. However, this now appears to be an outdated view of transcriptional control. In this study… CONTINUE READING
    93 Citations
    Genomic Determinants of Vitamin D-Regulated Gene Expression.
    • 35
    Emerging regulatory paradigms for control of gene expression by 1,25-dihydroxyvitamin D3
    • 42
    Regulation of target gene expression by the vitamin D receptor - an update on mechanisms
    • 88
    Genome-wide principles of gene regulation by the vitamin D receptor and its activating ligand
    • J. Pike
    • Biology, Medicine
    • Molecular and Cellular Endocrinology
    • 2011
    • 62
    Fundamentals of vitamin D hormone-regulated gene expression
    • J. Pike, Mark B Meyer
    • Biology, Medicine
    • The Journal of Steroid Biochemistry and Molecular Biology
    • 2014
    • 84
    Genomic Determinants of Gene Regulation by 1,25-Dihydroxyvitamin D3 during Osteoblast-lineage Cell Differentiation*♦
    • 72
    • PDF
    Regulation of gene expression by 1,25-dihydroxyvitamin D3 in bone cells: exploiting new approaches and defining new mechanisms.
    • 56
    • PDF

    References

    SHOWING 1-10 OF 33 REFERENCES
    Perspectives on mechanisms of gene regulation by 1,25-dihydroxyvitamin D3 and its receptor
    • 62
    Enhancers located in the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3
    • 35
    Regulation of 25‐hydroxyvitamin D3‐24‐hydroxylase mRNA by 1,25‐dihydroxyvitamin D3 and parathyroid hormone
    • 110
    1,25‐Dihydroxyvitamin D3 Stimulates Cyclic Vitamin D Receptor/Retinoid X Receptor DNA‐Binding, Co‐activator Recruitment, and Histone Acetylation in Intact Osteoblasts
    • S. Kim, N. Shevde, J. Pike
    • Biology, Medicine
    • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
    • 2005
    • 179
    Molecular Nature of the Vitamin D Receptor and its Role in Regulation of Gene Expression
    • 251