Genome-wide analysis of protein-DNA interactions.

  title={Genome-wide analysis of protein-DNA interactions.},
  author={Tae Hoon Kim and Bing Ren},
  journal={Annual review of genomics and human genetics},
The human genome is predominantly composed of nonprotein-coding sequences whose function remains largely undefined. A significant portion of the noncoding DNA is believed to serve as transcriptional regulatory elements that control gene expression in specific cell types at appropriate developmental stages. Identifying these regulatory sequences and determining the mechanisms by which they act present a great challenge in the postgenomic era. Previous investigations using genetic, molecular, and… CONTINUE READING
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