Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis

@article{Pelkmans2005GenomewideAO,
  title={Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis},
  author={Lucas Pelkmans and Eugenio Fava and Hannes Grabner and Michael Hannus and Bianca H Habermann and Eberhard Krausz and Marino Zerial},
  journal={Nature},
  year={2005},
  volume={436},
  pages={78-86}
}
Endocytosis is a key cellular process, encompassing different entry routes and endocytic compartments. To what extent endocytosis is subjected to high-order regulation by the cellular signalling machinery remains unclear. Using high-throughput RNA interference and automated image analysis, we explored the function of human kinases in two principal types of endocytosis: clathrin- and caveolae/raft-mediated endocytosis. We monitored this through infection of vesicular stomatitis virus, simian… CONTINUE READING
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