Genome-wide analysis of host responses to the Pseudomonas aeruginosa type III secretion system yields synergistic effects.

@article{Ichikawa2005GenomewideAO,
  title={Genome-wide analysis of host responses to the Pseudomonas aeruginosa type III secretion system yields synergistic effects.},
  author={Jeffrey K. Ichikawa and Sangeeta B. English and Matthew C Wolfgang and Rebekah Jackson and Atul J Butte and Stephen Lory},
  journal={Cellular microbiology},
  year={2005},
  volume={7 11},
  pages={1635-46}
}
The type III secretion system (TTSS) is a dedicated bacterial pathogen protein targeting system that directly affects host cell signalling and response pathways. Our goal was to identify host responses to the Pseudomonas aeruginosa effectors, introduced into target cells utilizing the TTSS. We carried out expression profiling of a human lung pneumocyte cell line A549 exposed to isogenic mutants of P. aeruginosa PAK lacking individual or a combination of TTSS components. We then devised a data… CONTINUE READING