Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy.

@article{Papait2013GenomewideAO,
  title={Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy.},
  author={Roberto Papait and Paola Cattaneo and Paolo Kunderfranco and Carolina M Greco and Pierluigi Carullo and Alessandro Guffanti and Valentina Vigan{\`o} and Giuliano Giuseppe Stirparo and Michael V. G. Latronico and Gerd Hasenfuss and Ju Chen and Gianluigi Condorelli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 50},
  pages={20164-9}
}
Cardiac hypertrophy, initially an adaptive response of the myocardium to stress, can progress to heart failure. The epigenetic signature underlying this phenomenon is poorly understood. Here, we report on the genome-wide distribution of seven histone modifications in adult mouse cardiomyocytes subjected to a prohypertrophy stimulus in vivo. We found a set of promoters with an epigenetic pattern that distinguishes specific functional classes of genes regulated in hypertrophy and identified 9,207… CONTINUE READING
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