Genome-wide analysis of dietary eicosapentaenoic acid- and oleic acid-induced modulation of colon inflammation in interleukin-10 gene-deficient mice.

@article{Knoch2009GenomewideAO,
  title={Genome-wide analysis of dietary eicosapentaenoic acid- and oleic acid-induced modulation of colon inflammation in interleukin-10 gene-deficient mice.},
  author={Bianca Knoch and Matthew P. G. Barnett and Shuotun Zhu and Zaneta A. Park and Katia Nones and Yvonne E M Dommels and Scott O Knowles and Warren C. McNabb and Nicole C Roy},
  journal={Journal of nutrigenetics and nutrigenomics},
  year={2009},
  volume={2 1},
  pages={9-28}
}
BACKGROUND/AIMS Dietary n-3 polyunsaturated fatty acids can reduce inflammation via a range of mechanisms. This study tested the effect of dietary eicosapentaenoic acid (EPA) on intestinal inflammation using interleukin-10 gene-deficient (Il10(-/-)) mice. METHODS At 35 days of age, 12 weaned Il10(-/-) and 12 C57 mice were randomly assigned to one of two modified AIN-76A diets, supplemented with 3.7% purified ethyl esters of either EPA (n-3) or oleic acid (OA, control). To identify genes… CONTINUE READING
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