Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues.

@article{Zhang2005GenomewideAO,
  title={Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues.},
  author={Xinmin Zhang and Duncan T. Odom and Seung-Hoi Koo and Michael D. Conkright and Gianluca Canettieri and Jennifer M Birkenhauer Best and Huaming Chen and Richard G Jenner and Elizabeth Herbolsheimer and Elizabeth A. Jacobsen and Shilpa Kadam and Joseph R. Ecker and Beverly M. Emerson and John B. Hogenesch and Terry G. Unterman and Richard A. Young and Marc R. Montminy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 12},
  pages={
          4459-64
        }
}
Hormones and nutrients often induce genetic programs via signaling pathways that interface with gene-specific activators. Activation of the cAMP pathway, for example, stimulates cellular gene expression by means of the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB) at Ser-133. Here, we use genome-wide approaches to characterize target genes that are regulated by CREB in different cellular contexts. CREB was found to occupy approximately 4,000 promoter sites in vivo… CONTINUE READING

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