Genome-wide analysis of androgen receptor binding sites in prostate cancer cells.

@article{Cheng2015GenomewideAO,
  title={Genome-wide analysis of androgen receptor binding sites in prostate cancer cells.},
  author={Yue Cheng and Pan Yu and Xiuzhi Duan and Chunhua Liu and Siqi Xu and Yuhua Chen and Yunnian Tan and Yun Qiang and Junfang Shen and Zhihua Tao},
  journal={Experimental and therapeutic medicine},
  year={2015},
  volume={9 6},
  pages={
          2319-2324
        }
}
The transformation of prostate cancer from an androgen-dependent state to an androgen-independent state is a lethal progression. Alterations in transcriptional programs are the basis of prostate cancer deterioration. The androgen receptor (AR), a member of the nuclear hormone receptor superfamily, mediates prostate cancer progression by functioning primarily through the ligand-activated transcription of target genes. Therefore, a detailed map of AR-regulated genes and AR genomic binding sites… 

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