Genome-wide analysis of RNA–protein interactions illustrates specificity of the mRNA export machinery

@article{Hieronymus2003GenomewideAO,
  title={Genome-wide analysis of RNA–protein interactions illustrates specificity of the mRNA export machinery},
  author={Haley Hieronymus and Pamela A. Silver},
  journal={Nature Genetics},
  year={2003},
  volume={33},
  pages={155-161}
}
Nuclear export of mRNA is mediated by a complex machinery of RNA-binding proteins that recognizes and routes mRNAs through a messenger ribonucleoprotein (mRNP) network. The full spectrum of mRNA cargoes for any dedicated mRNA export factor is unknown. We identified the mRNAs that bind two conserved yeast mRNA export factors, Yra1 (refs. 1–5) and Mex67 (refs. 6,7), on a genome-wide scale and determined their level of binding. Yra1 and Mex67 bind approximately 1,000 and 1,150 mRNAs, respectively… CONTINUE READING
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