Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.

@article{Akagi2014GenomewideAO,
  title={Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.},
  author={Keiko Akagi and Jingfeng Li and Tatevik R. Broutian and Hesed M. Padilla-Nash and Weihong Xiao and Bo Jiang and James W. Rocco and Theodoros Teknos and Bhavna Kumar and Danny Wangsa and Dandan He and Thomas Ried and David E. Symer and Maura L. Gillison},
  journal={Genome research},
  year={2014},
  volume={24 2},
  pages={185-99}
}
Genomic instability is a hallmark of human cancers, including the 5% caused by human papillomavirus (HPV). Here we report a striking association between HPV integration and adjacent host genomic structural variation in human cancer cell lines and primary tumors. Whole-genome sequencing revealed HPV integrants flanking and bridging extensive host genomic amplifications and rearrangements, including deletions, inversions, and chromosomal translocations. We present a model of "looping" by which… CONTINUE READING
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