Genome-wide analysis of H4K5 acetylation associated with fear memory in mice

@inproceedings{Park2013GenomewideAO,
  title={Genome-wide analysis of H4K5 acetylation associated with fear memory in mice},
  author={Christopher S. Park and Hubert Rehrauer and Isabelle M Mansuy},
  booktitle={BMC Genomics},
  year={2013}
}
Histone acetylation has been implicated in learning and memory in the brain, however, its function at the level of the genome and at individual genetic loci remains poorly investigated. This study examines a key acetylation mark, histone H4 lysine 5 acetylation (H4K5ac), genome-wide and its role in activity-dependent gene transcription in the adult mouse hippocampus following contextual fear conditioning. Using ChIP-Seq, we identified 23,235 genes in which H4K5ac correlates with absolute gene… CONTINUE READING
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