Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy

@inproceedings{Agardh2015GenomewideAO,
  title={Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy},
  author={Elisabet Agardh and Annika Lundstig and Alexander Perfilyev and Petr A Volkov and Tove Freiburghaus and Eero Lindholm and Tina R{\"o}nn and Carl David Agardh and Charlotte Ling},
  booktitle={BMC medicine},
  year={2015}
}
BACKGROUND Epigenetic variation has been linked to several human diseases. Proliferative diabetic retinopathy (PDR) is a major cause of vision loss in subjects with diabetes. However, studies examining the association between PDR and the genome-wide DNA methylation pattern are lacking. Our aim was to identify epigenetic modifications that associate with and predict PDR in subjects with type 1 diabetes (T1D). METHODS DNA methylation was analyzed genome-wide in 485,577 sites in blood from cases… CONTINUE READING
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