Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic

@article{Balklava2007GenomewideAI,
  title={Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic},
  author={Zita Balklava and Saumya Pant and Hanna Fares and Barth D Grant},
  journal={Nature Cell Biology},
  year={2007},
  volume={9},
  pages={1066-1073}
}
In a genome-wide RNA-mediated interference screen for genes required in membrane traffic — including endocytic uptake, recycling from endosomes to the plasma membrane, and secretion — we identified 168 candidate endocytosis regulators and 100 candidate secretion regulators. Many of these candidates are highly conserved among metazoans but have not been previously implicated in these processes. Among the positives from the screen, we identified PAR-3, PAR-6, PKC-3 and CDC-42, proteins that are… CONTINUE READING
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