Genome-wide analysis demonstrates conserved localization of messenger RNAs to mitotic microtubules

@article{Blower2007GenomewideAD,
  title={Genome-wide analysis demonstrates conserved localization of messenger RNAs to mitotic microtubules},
  author={Michael D Blower and Elma Feric and Karsten Weis and Rebecca Heald},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={179},
  pages={1365 - 1373}
}
RNA localization is of critical importance in many fundamental cell biological and developmental processes by regulating the spatial control of gene expression. To investigate how spindle-localized RNAs might influence mitosis, we comprehensively surveyed all messenger RNAs (mRNAs) that bound to microtubules during metaphase in both Xenopus laevis egg extracts and mitotic human cell extracts. We identify conserved classes of mRNAs that are enriched on microtubules in both human and X. laevis… CONTINUE READING
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