Genome-wide analysis correlates Ayurveda Prakriti

  title={Genome-wide analysis correlates Ayurveda Prakriti},
  author={Periyasamy Govindaraj and Sheikh Nizamuddin and Anugula Sharath and Vuskamalla Jyothi and Harish Rotti and Ritu Raval and Jayakrishna Nayak and Balakrishna K. Bhat and B. V. Prasanna and Pooja Shintre and Mayura Sule and Kalpana Joshi and Amrish P. Dedge and Ramachandra Bharadwaj and G. G. Gangadharan and Sreekumaran Nair and Puthiya Mundyat Gopinath and Bhushan Patwardhan and Paturu Kondaiah and Kapaettu Satyamoorthy and Marthanda Varma Sankaran Valiathan and Kumarasamy Thangaraj},
  journal={Scientific Reports},
The practice of Ayurveda, the traditional medicine of India, is based on the concept of three major constitutional types (Vata, Pitta and Kapha) defined as “Prakriti”. To the best of our knowledge, no study has convincingly correlated genomic variations with the classification of Prakriti. In the present study, we performed genome-wide SNP (single nucleotide polymorphism) analysis (Affymetrix, 6.0) of 262 well-classified male individuals (after screening 3416 subjects) belonging to three… 

Predictive, Preventive and Personalized Medicine: Leads From Ayurvedic Concept of Prakriti (Human Constitution)

Ayurvedic Prakriti-based treatment resonates with PM and pharmacogenomics and holds potential and promise for future predictive or preventive medicine.

Recapitulation of Ayurveda constitution types by machine learning of phenotypic traits

This study is the first to demonstrate that Prakriti types are distinct verifiable clusters within a multidimensional space of multiple interrelated phenotypic traits within a genetically homogeneous population of Western India.

Prakriti phenotypes as a stratifier of gut microbiome: A new frontier in personalized medicine?

An Ayurgenomics Approach: Prakriti-Based Drug Discovery and Development for Personalized Care

This work tries to understand prakriti’s use in personalized medicine, and how to integrate it with programs for drug development and discovery.

Correlations between blood group and dominant Prakriti based on the Tridosha concept of Ayurveda

Analysis of relation between Tridoshas with blood groups (ABO system) in healthy individuals showed no significant association (p>0.05) between the dominant Prakriti and the blood group of an individual, however, Pitta dosha was found predominant among all blood groups of the sample population.

Comparative gut microbiome analysis of the Prakriti and Sasang systems reveals functional level similarities in constitutionally similar classes

The gut microbiome functional-level similarities are found to correlate well with the host phenotypes of the constitutionally similar Prakriti and Sasang classes, which harboured the highest number of biofilm-forming and stress-tolerant microbes thus exhibiting the maximum tolerance of environmental stress.

Genesis of Personalized Medicine: Relevance of Ayurveda in the PresentMillennium

Several genomic and metabolomic studies augmented the possibilities of yet undisclosed molecular and genetic basis of Ayurveda, which could further be integrated or complemented to current medical diagnosis and treatment.

Understanding the association between the human gut, oral and skin microbiome and the Ayurvedic concept of prakriti

Bacteria known for preventing gut inflammation by digesting the resistant starch were abundant in the pitta prakriti individuals, who are more prone to develop gut-inflammation-related disorders.


Prakriti emphasizes on the individuality and plays an important role in diagnosis, preventive medicine, and therapeutics, one of the earliest known concepts of preventive and personalized or genomic medicine.



Whole genome expression and biochemical correlates of extreme constitutional types defined in Ayurveda

This study makes a first attempt towards unraveling the clinical phenotyping principle of a traditional system of medicine in terms of modern biology using Ayurveda based method of phenotypic classification of extreme constitutional types.

Classification of human population based on HLA gene polymorphism and the concept of Prakriti in Ayurveda.

It is hypothesized that there could be a genetic basis for the three major constitutions (Prakriti) described in Ayurveda and this may provide an appropriate means of classifying phenotypes to be considered collectively for genotyping.

Prakriti (Ayurvedic concept of constitution) and variations in platelet aggregation

It is observed that in the study population of normal healthy participants, ADP-induced maximal platelet aggregation (MPA) was highest among the Vata-pitta prakriti individuals and these individuals responded better to lower dose of aspirin compared to other prariti types.

Traditional Medicine to Modern Pharmacogenomics: Ayurveda Prakriti Type and CYP2C19 Gene Polymorphism Associated with the Metabolic Variability

Interesting correlations between CYP2C19 genotypes and Prakriti with fast and slow metabolism being one of the major distinguishing and differentiating characteristics are observed.

Determinants of Prakriti, the Human Constitution Types of Indian Traditional Medicine and its Correlation with Contemporary Science

Analysis of prakriti classification and its association with BMI and place of birth with the implications to one of the ways for human classification is demonstrated.

EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda

A link between high-altitude adaptation and common variations rs479200 (C/T) and rs480902 (T/C) in the EGLN1 gene is reported, and a genotype rare in highlanders but overrepresented in a subgroup of normal lowlanders discernable by Ayurveda may confer increased risk for high-ALTitude pulmonary edema.

Potential of Ayurgenomics Approach in Complex Trait Research: Leads from a Pilot Study on Rheumatoid Arthritis

This exploratory study suggests discrete causal pathways for RA etiology in prakriti based subgroups, thereby, validating concepts of prariti and personalized medicine in Ayurveda.

Immunophenotyping of normal individuals classified on the basis of human dosha prakriti

The increased level of CD25 and CD56 in kapha prakriti may indicate ability to elicit better immune response, which is in conformity with textual references in Ayurveda.

DNA methylation analysis of phenotype specific stratified Indian population

Differentially methylated regions in CpG islands and shores were significantly enriched in promoters/UTRs and gene body regions, demonstrating the epigenetic basis of Indian traditional human classification which may have relevance to personalized medicine.

Association of constitutional type of Ayurveda with cardiovascular risk factors, inflammatory markers and insulin resistance

There is strong relation of risk factors (diabetes, hypertension, dyslipidemia), insulin resistance, and inflammatory markers with Vata Kapha and Kapha Prakriti.