Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B

@inproceedings{Karlsson2013GenomewideAI,
  title={Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B},
  author={Elinor K Karlsson and Snaevar Sigurdsson and Emma L. Ivansson and Rachael Thomas and Ingegerd Elvers and Jason B Wright and C{\'e}dric Howald and Noriko Tonomura and Michele Perloski and Ross Swofford and Tara M Biagi and Sarah Fryc and Nathan E Anderson and C{\'e}line Courtay-Cahen and Lisa Youell and Sally L Ricketts and Sarah A Mandlebaum and Patricio Rivera and Henrik P von Euler and William C. Kisseberth and Cheryl A London and Eric S. Lander and Guillermo Couto and Kenine E Comstock and M P Starkey and Jaime F Modiano and Matthew Breen and Kerstin Lindblad-Toh},
  booktitle={Genome Biology},
  year={2013}
}
Canine osteosarcoma is clinically nearly identical to the human disease, but is common and highly heritable, making genetic dissection feasible. Through genome-wide association analyses in three breeds (greyhounds, Rottweilers, and Irish wolfhounds), we identify 33 inherited risk loci explaining 55% to 85% of phenotype variance in each breed. The greyhound locus exhibiting the strongest association, located 150 kilobases upstream of the genes CDKN2A/B, is also the most rearranged locus in… CONTINUE READING
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Ageilan RI: miRNA signatures associate with pathogenesis and progression of osteosarcoma

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Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B

  • Karlsson
  • http://www.broadinstitute.org/ftp/pub/vgb/dog…
  • 2013
1 Excerpt

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