Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax.

@article{Fang2014GenomewideAC,
  title={Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax.},
  author={Xiaodong Fang and Eviatar Nevo and Lijuan Han and Erez Y. Levanon and Jing Zhao and Aaron Avivi and Denis Larkin and Xuanting Jiang and S. I. Feranchuk and Yabing Zhu and Alla Fishman and Yue Feng and Noa Sher and Zhiqiang Xiong and Thomas Hankeln and Zhiyong Huang and Vera Gorbunova and Lu Zhang and Wei Zhao and Derek E. Wildman and Yingqi Xiong and Andrei V. Gudkov and Qiumei Zheng and Gideon Rechavi and Sanyang Liu and Lily Bazak and Jie Chen and Binyamin A Knisbacher and Yao Lu and Imad Shams and Krzysztof Gajda and Marta Farr{\'e} and Jaebum Kim and Harris A. Lewin and Jian Ma and Mark Band and Anne Bicker and Angela Kranz and Tobias Mattheus and Hanno Schmidt and Andrei Seluanov and Jorge Azpurua and Michael McGowen and Eshel Ben Jacob and Kexin Li and Shaoliang Peng and Xiaoqian Zhu and Xiangke Liao and Shuaicheng Li and Anders Krogh and Xin Zhou and Leonid Brodsky and Jun Wang},
  journal={Nature communications},
  year={2014},
  volume={5},
  pages={
          3966
        }
}
The blind mole rat (BMR), Spalax galili, is an excellent model for studying mammalian adaptation to life underground and medical applications. The BMR spends its entire life underground, protecting itself from predators and climatic fluctuations while challenging it with multiple stressors such as darkness, hypoxia, hypercapnia, energetics and high pathonecity. Here we sequence and analyse the BMR genome and transcriptome, highlighting the possible genomic adaptive responses to the underground… CONTINUE READING
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