Genome-wide aberrant DNA methylation of microRNA host genes in hepatocellular carcinoma.

  title={Genome-wide aberrant DNA methylation of microRNA host genes in hepatocellular carcinoma.},
  author={Jing Shen and Shuang Wang and Yu-jing Zhang and Maya Kappil and Hui Chen Wu and Muhammad G Kibriya and Qiao Wang and Farzana Jasmine and Habibul Ahsan and Po-huang Lee and M W Yu and C. -J. Chen and Regina M. Santella},
  volume={7 11},
Mature microRNAs (miRNAs) are a class of small non-coding RNAs involved in posttranslational gene silencing. Previous studies found that downregulation of miRNAs is a common feature observed in solid tumors, including hepatocellular carcinoma (HCC). We employed a genome-wide approach to test the hypothesis that DNA methylation alterations in miRNA host genes may cause deregulated miRNA expression in HCC. We analyzed tumor and adjacent non-tumor tissues from 62 Taiwanese HCC cases using Infinium… CONTINUE READING

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