Genome-wide SNP typing reveals signatures of population history.

@article{Hughes2008GenomewideST,
  title={Genome-wide SNP typing reveals signatures of population history.},
  author={Austin L. Hughes and Robert Welch and Vinita Puri and Casey Matthews and Kashif Haque and Stephen J. Chanock and Meredith Yeager},
  journal={Genomics},
  year={2008},
  volume={92 1},
  pages={1-8}
}
Single-nucleotide polymorphism (SNP) arrays have become a popular technology for disease-association studies, but they also have potential for studying the genetic differentiation of human populations. Application of the Affymetrix GeneChip Human Mapping 500K Array Set to a population of 102 individuals representing the major ethnic groups in the United States (African, Asian, European, and Hispanic) revealed patterns of gene diversity and genetic distance that reflected population history. We… CONTINUE READING
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