Genome-wide RNAi screen identifies SEC61A and VCP as conserved regulators of Sindbis virus entry.

@article{Panda2013GenomewideRS,
  title={Genome-wide RNAi screen identifies SEC61A and VCP as conserved regulators of Sindbis virus entry.},
  author={Debasis Panda and Patrick P. Rose and Sheri Hanna and Beth Gold and Kaycie C Hopkins and Randolph B Lyde and Michael S Marks and S. N. Cherry},
  journal={Cell reports},
  year={2013},
  volume={5 6},
  pages={1737-48}
}
Alphaviruses are a large class of insect-borne human pathogens and little is known about the host-factor requirements for infection. To identify such factors, we performed a genome-wide RNAi screen using model Drosophila cells and validated 94 genes that impacted infection of Sindbis virus (SINV), the prototypical alphavirus. We identified a conserved role for SEC61A and valosin-containing protein (VCP) in facilitating SINV entry in insects and mammals. SEC61A and VCP selectively regulate… CONTINUE READING
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