Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy.

@article{Lefebvre2013GenomewideRS,
  title={Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy.},
  author={Valerie Lefebvre and Qiujiang Du and S. Baird and Andy Ng and Mirna Gisele Medeiros do Nascimento and Michelangelo Campanella and Heidi M McBride and Robert A. Screaton},
  journal={Autophagy},
  year={2013},
  volume={9 11},
  pages={1770-9}
}
Mitochondrial dysfunction is a hallmark of aging and numerous human diseases, including Parkinson disease (PD). Multiple homeostatic mechanisms exist to ensure mitochondrial integrity, including the selective autophagic program mitophagy, that is activated during starvation or in response to mitochondrial dysfunction. Following prolonged loss of potential across the inner mitochondrial membrane (ΔΨ), PTEN-induced putative kinase 1 (PINK1) and the E3-ubiquitin ligase PARK2 work in the same… CONTINUE READING

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