Genome-wide RNA polymerase II: not genes only!

@article{Koch2008GenomewideRP,
  title={Genome-wide RNA polymerase II: not genes only!},
  author={Frederic Koch and Fr{\'e}d{\'e}ric Jourquin and Pierre Ferrier and Jean-Christophe Andrau},
  journal={Trends in biochemical sciences},
  year={2008},
  volume={33 6},
  pages={
          265-73
        }
}
RNA polymerase (Pol) II transcriptional regulation is an essential process for guiding eukaryotic gene expression. Early in vitro studies deciphered the essential steps for transcription, including recruitment, initiation, elongation and termination. Based on these findings, the idea emerged that Pol II should essentially be located on promoters or genic regions of transcribed genes. The development of in vivo localization protocols has enabled the investigation of genome-wide Pol II occupancy… CONTINUE READING
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