Genome-wide DNA microarray analysis of Francisella tularensis strains demonstrates extensive genetic conservation within the species but identifies regions that are unique to the highly virulent F. tularensis subsp. tularensis.

@article{Broekhuijsen2003GenomewideDM,
  title={Genome-wide DNA microarray analysis of Francisella tularensis strains demonstrates extensive genetic conservation within the species but identifies regions that are unique to the highly virulent F. tularensis subsp. tularensis.},
  author={Martien Broekhuijsen and P{\"a}r Larsson and Anders Johansson and Mona Bystr{\"o}m and Ulla C Eriksson and Eva Larsson and Richard G Prior and Anders Sj{\"o}stedt and Richard W. Titball and Mats Forsman},
  journal={Journal of clinical microbiology},
  year={2003},
  volume={41 7},
  pages={2924-31}
}
Francisella tularensis is a potent pathogen and a possible bioterrorism agent. Little is known, however, to explain the molecular basis for its virulence and the distinct differences in virulence found between the four recognized subspecies, F. tularensis subsp. tularensis, F. tularensis subsp. mediasiatica, F. tularensis subsp. holarctica, and F. tularensis subsp. novicida. We developed a DNA microarray based on 1,832 clones from a shotgun library used for sequencing of the highly virulent… CONTINUE READING
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