Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage.

  title={Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage.},
  author={Matlock A. Jeffries and Madison Donica and Lyle W Baker and Michael Eric Stevenson and Anand C Annan and Mary Beth Humphrey and Judith A James and Amr H. Sawalha},
  journal={Arthritis & rheumatology},
  volume={66 10},
OBJECTIVE To perform a genome-wide DNA methylation study to identify DNA methylation changes in osteoarthritic (OA) cartilage tissue. METHODS The contribution of differentially methylated genes to OA pathogenesis was assessed by bioinformatic analysis, gene expression analysis, and histopathologic severity correlation. Genome-wide DNA methylation profiling of >485,000 methylation sites was performed on eroded and intact cartilage from within the same joint of 24 patients undergoing hip… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 39 extracted citations


Publications referenced by this paper.
Showing 1-10 of 51 references

A meta - analysis of genome - wide association studies identifies novel variants associated with osteoarthritis of the hip

  • MA Jeffries, M Dozmorov, Y Tang, JT Merrill, JD Wren, AH Sawalha
  • Ann Rheum Dis
  • 2013

Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression

  • L de la Rica, JM Urquiza, D Gomez-Cabrero, AB Islam, N LopezBigas, J Tegner
  • J Autoimmun 2013;41:6–16
  • 2013

Similar Papers

Loading similar papers…