Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites.

@article{Hogart2012GenomewideDM,
  title={Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites.},
  author={Amber Hogart and Jens Lichtenberg and Subramanian Shankar Ajay and Stacie M. Anderson and Elliott H. Margulies and David M. Bodine},
  journal={Genome research},
  year={2012},
  volume={22 8},
  pages={
          1407-18
        }
}
DNA methylation is an essential epigenetic mark that is required for normal development. Knockout of the DNA methyltransferase enzymes in the mouse hematopoietic compartment reveals that methylation is critical for hematopoietic differentiation. To better understand the role of DNA methylation in hematopoiesis, we characterized genome-wide DNA methylation in primary mouse hematopoietic stem cells (HSCs), common myeloid progenitors (CMPs), and erythroblasts (ERYs). Methyl binding domain protein… CONTINUE READING
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