Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus.

@article{Jeffries2011GenomewideDM,
  title={Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus.},
  author={Matlock A. Jeffries and Mikhail Dozmorov and Yuhong Tang and Joan Tenenbaum Merrill and Jonathan D. Wren and Amr H. Sawalha},
  journal={Epigenetics},
  year={2011},
  volume={6 5},
  pages={593-601}
}
Systemic lupus erythematosus is a chronic-relapsing autoimmune disease of incompletely understood etiology. Recent evidence strongly supports an epigenetic contribution to the pathogenesis of lupus. To understand the extent and nature of dysregulated DNA methylation in lupus T cells, we performed a genome-wide DNA methylation study in CD4 (+) T cells in lupus patients compared to normal healthy controls. Cytosine methylation was quantified in 27,578 CG sites located within the promoter regions… CONTINUE READING

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