Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes.

@article{Birdwell2014GenomewideDM,
  title={Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes.},
  author={Christine E. Birdwell and Krista J Queen and Phillip Kilgore and Phoebe A Rollyson and Marjan Trutschl and Urska Cvek and Rona S. Scott},
  journal={Journal of virology},
  year={2014},
  volume={88 19},
  pages={11442-58}
}
UNLABELLED The oral cavity is a persistent reservoir for Epstein-Barr virus (EBV) with lifelong infection of resident epithelial and B cells. Infection of these cell types results in distinct EBV gene expression patterns regulated by epigenetic modifications involving DNA methylation and chromatin structure. Regulation of EBV gene expression relies on viral manipulation of the host epigenetic machinery that may result in long-lasting host epigenetic reprogramming. To identify epigenetic events… CONTINUE READING
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