Genome-wide Association Analyses Suggested a Novel Mechanism for Smoking Behavior Regulated by IL15

@inproceedings{Liu2009GenomewideAA,
  title={Genome-wide Association Analyses Suggested a Novel Mechanism for Smoking Behavior Regulated by IL15},
  author={Y W Liu and Yu-Fang Pei and Yan-Fang Guo and Liang Wang and Xiao-gang Liu and Han Yan and Dong-hai Xiong and Y X Zhang and Tian-bo Jin and Shawn E. Levy and Christopher keith Haddock and Christopher J. Papasian and Qing Xu and Jennie Z Ma and Thomas J. Payne and Robert Roy Recker and Ming D. Li and Hong-Wen Deng},
  booktitle={Molecular Psychiatry},
  year={2009}
}
Cigarette smoking is the leading preventable cause of death in the United States. Although smoking behavior has a significant genetic determination, the specific genes and associated mechanisms underlying the smoking behavior are largely unknown. Here, we carried out a genome-wide association study on smoking behavior in 840 Caucasians, including 417 males and 423 females, in which we examined ∼380 000 single nucleotide polymorphisms (SNPs). We found that a cluster of nine SNPs upstream from… CONTINUE READING

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