Genome-wide A-to-I RNA editing in fungi independent of ADAR enzymes.

@article{Liu2016GenomewideAR,
  title={Genome-wide A-to-I RNA editing in fungi independent of ADAR enzymes.},
  author={Huiquan Liu and Qinhu Wang and Yi He and Lingfeng Chen and Chaofeng Hao and Cong Jiang and Yang Li and Yafeng Dai and Z Kang and Jin-Rong Xu},
  journal={Genome research},
  year={2016},
  volume={26 4},
  pages={499-509}
}
Yeasts and filamentous fungi do not have adenosine deaminase acting on RNA (ADAR) orthologs and are believed to lack A-to-I RNA editing, which is the most prevalent editing of mRNA in animals. However, during this study with the PUK1(FGRRES_01058) pseudokinase gene important for sexual reproduction in Fusarium graminearum, we found that two tandem stop codons, UA(1831)GUA(1834)G, in its kinase domain were changed to UG(1831)GUG(1834)G by RNA editing in perithecia. To confirm A-to-I editing of… CONTINUE READING
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