Genome variation and meiotic recombination in Plasmodium falciparum : insights from deep sequencing of genetic crosses

@inproceedings{Miles2015GenomeVA,
  title={Genome variation and meiotic recombination in Plasmodium falciparum : insights from deep sequencing of genetic crosses},
  author={Alistair Miles and Zamin Iqbal and Paul Vauterin and Richard Pearson and Susana G. Campino and M. Theron and Kelda Gould and Daniel Mead and Eleanor Drury and John O’Brien and Valentin Ruano Rubio and Bronwyn Macinnis and Jonathan Mwangi and Upeka Samarakoon and Lisa C Ranford-Cartwright and Michael T. Ferdig and Karen Hayton and Xin-Zhuan Su and Thomas E Wellems and Julian C. Rayner and Gilean McVean and Dominic Kwiatkowski},
  year={2015}
}
The malaria parasite Plasmodium falciparum has a great capacity for evolutionary adaptation to evade host immunity and develop drug resistance. Current understanding of parasite evolution is impeded by the fact that a large fraction of the genome is either highly repetitive or highly variable, and thus difficult to analyse using short read technologies… CONTINUE READING