Genome stability control by checkpoint regulation of tRNA gene transcription.

@article{Clelland2010GenomeSC,
  title={Genome stability control by checkpoint regulation of tRNA gene transcription.},
  author={Brett W Clelland and Michael Schultz},
  journal={Transcription},
  year={2010},
  volume={1 3},
  pages={115-125}
}
The RNA polymerase III pre-initiation complex (PIC) assembled on yeast tRNA genes naturally causes replication fork pausing that contributes to genome instability. Mechanistic coupling of the fork pausing activity of tRNA genes to replication has long been considered likely, but only recently demonstrated. In contrast to the expectation that this coupling might occur by a passive mechanism such as direct disruption of transcription factor-DNA complexes by a component of the replisome, it turns… CONTINUE READING