Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance

@article{Zhang2013GenomeSO,
  title={Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance},
  author={H. Zhang and D. Li and L. Zhao and Joy Fleming and N. Lin and T. Wang and Z. Liu and C. Li and N. Galwey and Jiaoyu Deng and Y. Zhou and Y. Zhu and Yunrong Gao and Shihua Wang and Yu-fen Huang and Ming Wang and Qiu Zhong and L. Zhou and T. Chen and J. Zhou and R. Yang and Guofeng Zhu and H. Hang and J. Zhang and Fabin Li and K. Wan and J. Wang and X. Zhang and L. Bi},
  journal={Nature Genetics},
  year={2013},
  volume={45},
  pages={1255-1260}
}
  • H. Zhang, D. Li, +27 authors L. Bi
  • Published 2013
  • Biology, Medicine
  • Nature Genetics
  • The worldwide emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis threatens to make this disease incurable. Drug resistance mechanisms are only partially understood, and whether the current understanding of the genetic basis of drug resistance in M. tuberculosis is sufficiently comprehensive remains unclear. Here we sequenced and analyzed 161 isolates with a range of drug resistance profiles, discovering 72 new genes, 28 intergenic regions (IGRs), 11… CONTINUE READING
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