Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance

@article{Zhang2013GenomeSO,
  title={Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance},
  author={Hongtai Zhang and Dongfang Li and Li-li Zhao and Joy Fleming and Nan Lin and Tingting Wang and Zhangyi Liu and Chuanyou Li and Nicholas W. Galwey and Jiao-yu Deng and Ying Zhou and Yuanfang Zhu and Yun-rong Gao and Tong Wang and Shihua Wang and Yufen Huang and Ming Wang and Qiu Zhong and Lin Zhou and Tao Chen and Jie Zhou and Ruifu Yang and Guofeng Zhu and Haiying Hang and Jia Zhang and Fabin Li and Kanglin Wan and Jun Wang and Xian-En Zhang and Li-jun Bi},
  journal={Nature Genetics},
  year={2013},
  volume={45},
  pages={1255-1260}
}
The worldwide emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis threatens to make this disease incurable. Drug resistance mechanisms are only partially understood, and whether the current understanding of the genetic basis of drug resistance in M. tuberculosis is sufficiently comprehensive remains unclear. Here we sequenced and analyzed 161 isolates with a range of drug resistance profiles, discovering 72 new genes, 28 intergenic regions (IGRs), 11… 
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