Genome sequencing and analysis of Aspergillus oryzae

@article{Machida2005GenomeSA,
  title={Genome sequencing and analysis of Aspergillus oryzae},
  author={Masayuki Machida and Kiyoshi Asai and Motoaki Sano and Toshihiro Tanaka and Toshitaka Kumagai and Goro Terai and Ken-ichi Kusumoto and Toshi-hide Arima and Osamu Akita and Yutaka Kashiwagi and Keietsu Abe and Katsuya Gomi and Hiroyuki Horiuchi and Katsuhiko Kitamoto and Tetsuo Kobayashi and Michio Takeuchi and David W. Denning and James E. Galagan and William C. Nierman and Jiujiang Yu and David Brian Archer and Joan W Bennett and Deepak Bhatnagar and Thomas E. Cleveland and Natalie D. Fedorova and Osamu Gotoh and Hiroshi Horikawa and Akira Hosoyama and Masayuki Ichinomiya and R. Igarashi and Kazuhiro Iwashita and Praveen R. Juvvadi and Masashi Kato and Yumiko Kato and Taishin Kin and Akira Kokubun and Hiroshi Maeda and Noriko Maeyama and Jun‐ichi Maruyama and Hideki Nagasaki and Tasuku Nakajima and Ken Oda and Kinya Okada and Ian T. Paulsen and Kazutoshi Sakamoto and Toshihiko Sawano and Mikio Takahashi and Kumiko Takase and Yasunobu Terabayashi and Jennifer R. Wortman and Osamu Yamada and Youhei Yamagata and Hideharu Anazawa and Yoji Hata and Yoshinao Koide and Takashi Komori and Yasuji Koyama and Toshitaka Minetoki and Sivasundaram Suharnan and Akimitsu Tanaka and Katsumi Isono and Satoru Kuhara and Naotake Ogasawara and Hisashi Kikuchi},
  journal={Nature},
  year={2005},
  volume={438},
  pages={1157-1161}
}
The genome of Aspergillus oryzae, a fungus important for the production of traditional fermented foods and beverages in Japan, has been sequenced. The ability to secrete large amounts of proteins and the development of a transformation system have facilitated the use of A. oryzae in modern biotechnology. Although both A. oryzae and Aspergillus flavus belong to the section Flavi of the subgenus Circumdati of Aspergillus, A. oryzae, unlike A. flavus, does not produce aflatoxin, and its long… 
Genomics of industrial Aspergilli and comparison with toxigenic relatives
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TLDR
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TLDR
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TLDR
It is shown that the presence of divergent pairs of paralogs is a feature peculiar to A. oryzae and is not shared with A. nidulans and A. fumigatus, and phylogenetic analysis did not however indicate a single consistent evolutionary origin for the divergent members of these pairs.
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TLDR
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TLDR
Several strain-specific genes of two strains are identified by genome sequences' comparison, and they are classified into some groups, which have the relationship with cell growth, cellular response and regulation, resistance, energy metabolism, salt tolerance, and flavor formation.
Comparative genome analysis of Aspergillus flavus clinically isolated in Japan
TLDR
The genome data obtained may be further explored and utilized for comparative analysis of aflatoxin production in environmental and clinical isolates of A. flavus and Aspergillus oryzae RIB40.
Comparison of Two Aspergillus oryzae Genomes From Different Clades Reveals Independent Evolution of Alpha-Amylase Duplication, Variation in Secondary Metabolism Genes, and Differences in Primary Metabolism
TLDR
The results provide evidence of independent evolution of the alpha-amylase gene duplication, which is one of the major adaptive mutations resulting from domestication and revealed substantial genome and phenotypic variation within A. oryzae.
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