Genome sequence of the nematode C. elegans: a platform for investigating biology.

@article{Berg1998GenomeSO,
  title={Genome sequence of the nematode C. elegans: a platform for investigating biology.},
  author={Jeremy M. Berg},
  journal={Science},
  year={1998},
  volume={282 5396},
  pages={
          2012-8
        }
}
  • J. Berg
  • Published 1998
  • Medicine
  • Science
The 97-megabase genomic sequence of the nematode Caenorhabditis elegans reveals over 19,000 genes. More than 40 percent of the predicted protein products find significant matches in other organisms. There is a variety of repeated sequences, both local and dispersed. The distinctive distribution of some repeats and highly conserved genes provides evidence for a regional organization of the chromosomes. 

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References

SHOWING 1-10 OF 30 REFERENCES
… genetics …
TLDR
A possible genetic aetiology to CSVT, provides reliable risk estimates and allows accurate comparison with genetic risk in other vascular conditions is supported.
Genome Res
  • Genome Res
  • 1998
Genome Res
  • Genome Res
  • 1998
Genome Res
  • Genome Res
  • 1998
Genome Res
  • Genome Res
  • 1998
Genomics
Comput. Appl. Biosci
  • Comput. Appl. Biosci
  • 1997
Genome Analysis: A Laboratory
  • For software packages,
  • 1997
Genome Res
  • Genome Res
  • 1997
Nucleic Acids Res
  • Nucleic Acids Res
  • 1997
...
1
2
3
...