Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.

@article{Anderson2008GenomeSO,
  title={Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.},
  author={Iain J. Anderson and Jason R Rodriguez and Dwi Susanti and Iris Porat and Claudia Reich and Luke E. Ulrich and James G. Elkins and Konstantinos Mavromatis and Athanasios Lykidis and Edwin S. Kim and Linda S. Thompson and Matt Nolan and Miriam Land and Alex Copeland and Alla Lapidus and Susan Lucas and Chris Detter and Igor B. Zhulin and Gary J. Olsen and William B. Whitman and Biswarup Mukhopadhyay and James Bristow and Nikos C Kyrpides},
  journal={Journal of bacteriology},
  year={2008},
  volume={190 8},
  pages={2957-65}
}
We report the complete genome of Thermofilum pendens, a deeply branching, hyperthermophilic member of the order Thermoproteales in the archaeal kingdom Crenarchaeota. T. pendens is a sulfur-dependent, anaerobic heterotroph isolated from a solfatara in Iceland. It is an extracellular commensal, requiring an extract of Thermoproteus tenax for growth, and the genome sequence reveals that biosynthetic pathways for purines, most amino acids, and most cofactors are absent. In fact, T. pendens has… CONTINUE READING