Genome sequence, comparative analysis and haplotype structure of the domestic dog

  title={Genome sequence, comparative analysis and haplotype structure of the domestic dog},
  author={Kerstin Lindblad-Toh and Claire M. Wade and Tarjei S. Mikkelsen and Elinor K Karlsson and David B. Jaffe and Michael Kamal and Michele Clamp and Jean L. Chang and Edward J. Kulbokas and Michael C. Zody and Evan Mauceli and Xiaohui Xie and Matthew Breen and Robert K. Wayne and Elaine A Ostrander and Chris P. Ponting and Francis Galibert and Douglas R. Smith and P Dejong and Ewen Kirkness and Pablo Lamilla Alvarez and Tara Biagi and William S. Brockman and Jonathan L. Butler and Chee-Wye Chin and A. Cook and James Cuff and Mark J. Daly and David DeCaprio and Sante Gnerre and Manfred G. Grabherr and Manolis Kellis and Michael Kleber and Carolyne Bardeleben and Leo Goodstadt and Andreas Heger and Christophe C. Hitte and Lisa Kim and Klaus-Peter Koepfli and Heidi G Parker and John P Pollinger and Stephen M. J. Searle and Nathan B. Sutter and Rachael Thomas and Caleb Webber and Eric S. Lander},
Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of… CONTINUE READING