Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis

  title={Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis},
  author={Roderick H. J. Houwen and Siamak Baharloo and Kathleen Blankenship and Peter Raeymaekers and J. Juyn and Lodewijk A. Sandkuijl and Nelson B. Freimer},
  journal={Nature Genetics},
It is now feasible to map disease genes by screening the genome for linkage disequilibrium between the disease and marker alleles. This report presents the first application of this approach for a previously unmapped locus. A gene for benign recurrent intrahepatic cholestasis (BRIC) was mapped to chromosome 18 by searching for chromosome segments shared by only three distantly related patients. The screening results were confirmed by identifying an extended haplotype conserved between the… 
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